Answer

To set customized settings with Profile function, please select "Profile 1" button before setting monitor items, after selecting "Profile 1" button you can proceed to set monitor settings.
Then before setting Profile 2, select "Profile 2" button first, then proceed to monitor settings.

The items which are avaiable for saving in "Profile 1", "Profile 2" option are "Brightness", "Contrast", "Color Temperature". The rest options are not available for saving in "Profile 1", "Profile 2" option(e.g. Dark Boost、Response Time, etc..)

To modify monitor settings for specific Profile, please follow above mentioned procedure, just choose "Profile 1" or "Profile 2" button and you can save settings once again.

To reset all the settings to default, please reset monitor as attached picture.

Reference